Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197571
Type: Artigo de periódico
Title: Influence Of Stimulus Frequency On Blockade Induced By Pancuronium And Rocuronium: Study On Rats Phrenic Nerve-diaphragm Preparation.
Author: Braga, Angélica de Fátima de Assunção
Munoz, Derli Conceição
Braga, Franklin Sarmento da Silva
Araujo, Daniele Ribeiro de
Potério, Glória Maria Braga
Mantovani, Mario
Abstract: To evaluate the influence of two stimulation frequencies on the installation of neuromuscular blockade produced by pancuronium and rocuronium on the rat diaphragm. Diaphragms were submitted to an indirect frequency stimulation of 0.1 and 1 Hz (Groups I and II, respectively). Subgroups were formed (n=5) according to the neuromuscular blocker employed (pancuronium-2 microg/ml and rocuronium-4 microg/ml). The twitch height depression was evaluated at 5, 15 and 30 minutes after adding the neuromuscular blocker. The decrease in twitch height was greater (p<0.01) with a frequency of 1 Hz at all time periods studied both in preparations that are blocked with pancuronium and in those that are blocked with rocuronium. The frequency of stimulation interferes significantly with the installation of neuromuscular blockade produced by pancuronium and rocuronium, since the reduction in amplitude of the rat diaphragm response was greater for 1 Hz frequencies, at all periods studied.
Subject: Androstanols
Animals
Diaphragm
Electric Stimulation
Male
Neuromuscular Blockade
Neuromuscular Nondepolarizing Agents
Pancuronium
Phrenic Nerve
Rats
Rats, Wistar
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/18235932
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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