Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197527
Type: Artigo de periódico
Title: Involvement Of Peripheral Trpv1 In Tmj Hyperalgesia Induced By Ethanol Withdrawal.
Author: Urtado, Marília Bertoldo
Gameiro, Gustavo Hauber
Tambeli, Cláudia Herrera
Fischer, Luana
Urtado, Christiano Bertoldo
de Arruda Veiga, Maria Cecília Ferraz
Abstract: Ethanol withdrawal increases nociception after the injection of formalin into the rat's temporomandibular joint (TMJ). Little is known about the neurological basis for hyperalgesia induced by ethanol withdrawal, but it has been reported that ethanol can potentiate the response of transient receptor potential vanilloid receptor-1 (TRPV1) in superficial tissues. The present study was designed to test the hypothesis that peripheral TRPV1 could be involved on nociceptive behavioral responses induced by the injection of formalin into the TMJ region of rats exposed to chronic ethanol administration and ethanol withdrawal. Behavioral hyperalgesia was verified 12 h after ethanol withdrawal in rats that drank an ethanol solution (6.5%) for 10 days. In another group submitted to the same ethanol regimen, the selective vanilloid receptor antagonist capsazepine (300, 600 or 1200 microg/25 microl) or an equal volume of vehicle were injected into the TMJ regions 30 min before the TMJ formalin test. The local injections of capsazepine reduced the increased nociceptive responses induced by ethanol withdrawal. The effect of capsazepine on rats that did not drink ethanol was not significant. These results indicate that the peripheral TRPV1 can contribute to the hyperalgesia induced by ethanol withdrawal on deep pain conditions.
Subject: Animals
Capsaicin
Central Nervous System Depressants
Ethanol
Formaldehyde
Male
Pain Measurement
Rats
Rats, Wistar
Substance Withdrawal Syndrome
Trpv Cation Channels
Temporomandibular Joint Dysfunction Syndrome
Rights: fechado
Identifier DOI: 10.1016/j.lfs.2007.10.002
Address: http://www.ncbi.nlm.nih.gov/pubmed/17977563
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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