Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197521
Type: Artigo de periódico
Title: Diminished Myelin-specific T Cell Activation Associated With Increase In Ctla4 And Fas Molecules In Multiple Sclerosis Patients Treated With Ifn-beta.
Author: Hallal-Longo, Dannie E M
Mirandola, Sandra R
Oliveira, Elaine C
Farias, Alessandro S
Pereira, Fernanda G
Metze, Irene L
Brandão, Carlos Otavio
Ruocco, Heloísa H
Damasceno, Benito P
Santos, Leonilda M B
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the white matter of the central nervous system (CNS) characterized by focal areas of demyelination. Interferon-beta (IFN-beta) provides an effective treatment that lessens the frequency and severity of exacerbations in relapsing-remitting multiple sclerosis (RRMS), but the mechanisms by which IFN-beta is efficient remain uncertain. The data presented here demonstrate that IFN-beta impairs the proliferative response to myelin basic protein (MBP) and myelin, as well as increasing the expression of the CTLA4 intracellular molecule. Moreover, this treatment increases the expression of surface Fas molecules and of the soluble form of these molecules. Our hypothesis is that the increase in Fas and CTLA4 molecules in MS patients may lead to lymphocyte apoptosis, which suggests possible mechanisms underlying the therapeutic response to IFN-beta.
Subject: Adult
Antigens, Cd
Antigens, Cd95
Antigens, Differentiation
Cd4-positive T-lymphocytes
Cd8-positive T-lymphocytes
Ctla-4 Antigen
Cell Proliferation
Female
Humans
Interferon-beta
Lymphocyte Activation
Male
Multiple Sclerosis
Myelin Basic Protein
Myelin Sheath
Solubility
T-lymphocytes
Rights: fechado
Identifier DOI: 10.1089/jir.2007.0018
Address: http://www.ncbi.nlm.nih.gov/pubmed/17970696
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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