Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197515
Type: Artigo de periódico
Title: Ovariectomy Delays Alveolar Wound Healing After Molar Extractions In Rats.
Author: Pereira, Michele Conceição
Zecchin, Karina Gottardello
Campagnoli, Eduardo Bauml
Jorge, Jacks
Abstract: This study was conducted to investigate the morphological effects of the absence of estrogen on alveolar wound healing of young female rats after tooth extraction. A total of 60 4- to 6-week-old female rats underwent bilateral ovariectomy (OVX) or sham operations. Three weeks later, the first mandibular molars were extracted. Subsequently, the animals were killed by cervical dislocation 3, 5, 7, 14, 21, or 28 days after tooth extraction. The mandibles were removed, and serial transversal sections of mesial alveolus of the first mandibular molars were obtained for histometric analysis. OVX sockets showed significant increases in fibroblasts and collagen content 3 and 5 days after the extractions, followed by significant decreases in these parameters in the subsequent periods. In accordance with the decreased collagen content in the latest period of healing, new bone formation was significantly reduced in the OVX animals. These findings suggest that the initial molecular changes observed in the absence of estrogen lead to delayed alveolar wound healing.
Subject: Absorptiometry, Photon
Alveolar Process
Animals
Bone Density
Collagen
Estrogens
Female
Fibroblasts
Mandible
Molar
Osteogenesis
Ovariectomy
Ovary
Rats
Rats, Wistar
Tibia
Time Factors
Tooth Extraction
Tooth Socket
Wound Healing
Rights: fechado
Identifier DOI: 10.1016/j.joms.2006.11.040
Address: http://www.ncbi.nlm.nih.gov/pubmed/17954321
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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