Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197504
Type: Artigo de periódico
Title: A Possible Anti-proliferative And Anti-metastatic Effect Of Irradiated Riboflavin In Solid Tumours.
Author: de Souza Queiroz, Karla Cristiana
Zambuzzi, Willian Fernando
Santos de Souza, Ana Carolina
da Silva, Rodrigo Augusto
Machado, Daisy
Justo, Giselle Zenker
Carvalho, Hernandes F
Peppelenbosch, Maikel P
Ferreira, Carmen Veríssima
Abstract: Riboflavin is a potent photosensitizer as well as part of the vitamin B complex. Recently we demonstrated that the products generated by irradiation of riboflavin have potential as anti-leukaemic therapy. The possible action, however, of the riboflavin photoproducts in solid cancers has not been addressed. Hence, we investigated the effects of irradiated riboflavin on androgen-independent human prostate cancer cells (PC3), a known model for solid tumour cells with an exceptional resistance to therapy. Our results show that riboflavin photoproducts are cytotoxic to these cells in a FasL-Fas-dependent manner. Furthermore, irradiated riboflavin inhibited matrix-degrading proteases, caused downregulation of VEGF and upregulation of TIMP1 suggesting anti-metastatic potential. Together, these results show that the anti-neoplastic action of riboflavin photoproducts is not limited to haematological malignancies, warranting clinical studies in solid tumours.
Subject: Animals
Apoptosis
Blotting, Western
Caspases
Cell Proliferation
Cells, Cultured
Hepatocytes
Humans
Male
Neoplasms, Hormone-dependent
Photosensitizing Agents
Prostate
Prostatic Neoplasms
Rats
Riboflavin
Rights: fechado
Identifier DOI: 10.1016/j.canlet.2007.08.024
Address: http://www.ncbi.nlm.nih.gov/pubmed/17933458
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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