Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197503
Type: Artigo de periódico
Title: The Effect Of Treatment With Crotapotin On The Evolution Of Experimental Autoimmune Neuritis Induced In Lewis Rats.
Author: Castro, Fabiano R
Farias, Alessandro S
Proença, Patricia L F
de La Hoz, Cristiane
Langone, Francesco
Oliveira, Elaine C
Toyama, Marcos H
Marangoni, Sergio
Santos, Leonilda M B
Abstract: Biomedical research in which venom components are being investigated for their potential as novel therapeutic agents has emerged as an interesting option. Crotapotin, which is purified from the venom of the rattlesnake Crotalus durissus terrificus, has been described as an anti-inflammatory agent that acts on the innate arm of the immune response. Here we have demonstrated that intraperitoneal administration of crotapotin significantly reduces the severity of experimental autoimmune neuritis (EAN), an experimental model for Guillain-Barré syndrome. The reduction of the severity of the disease is associated with a reduction in the mononuclear cells infiltrating the sciatic nerve and a significant decrease in the lymphocyte proliferative response to neuritogenic peptide.
Subject: Animals
Anti-inflammatory Agents
Cell Proliferation
Cells, Cultured
Chromatography, High Pressure Liquid
Crotalus
Crotoxin
Disease Models, Animal
Dose-response Relationship, Immunologic
Female
Guillain-barre Syndrome
Injections, Intraperitoneal
Leukocytes, Mononuclear
Lymph Nodes
Lymphocyte Activation
Myelin Proteins
Neuritis, Autoimmune, Experimental
Rats
Rats, Inbred Lew
Sciatic Nerve
T-lymphocytes
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2006.09.028
Address: http://www.ncbi.nlm.nih.gov/pubmed/17145071
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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