Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197482
Type: Artigo de periódico
Title: Vernonia Polyanthes As A New Source Of Antiulcer Drugs.
Author: Barbastefano, Victor
Cola, Maira
Luiz-Ferreira, Anderson
Farias-Silva, Elisângela
Hiruma-Lima, Clélia A
Rinaldo, Daniel
Vilegas, Wagner
Souza-Brito, Alba R M
Abstract: Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action.
Subject: Animals
Anti-inflammatory Agents, Non-steroidal
Anti-ulcer Agents
Dose-response Relationship, Drug
Ethanol
Male
Phytotherapy
Plant Components, Aerial
Plant Extracts
Rats
Rats, Wistar
Stomach Ulcer
Vernonia
Rights: fechado
Identifier DOI: 10.1016/j.fitote.2007.07.003
Address: http://www.ncbi.nlm.nih.gov/pubmed/17904766
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_17904766.pdf264.25 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.