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Type: Artigo de periódico
Title: Vernonia Polyanthes As A New Source Of Antiulcer Drugs.
Author: Barbastefano, Victor
Cola, Maira
Luiz-Ferreira, Anderson
Farias-Silva, Elisângela
Hiruma-Lima, Clélia A
Rinaldo, Daniel
Vilegas, Wagner
Souza-Brito, Alba R M
Abstract: Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action.
Subject: Animals
Anti-inflammatory Agents, Non-steroidal
Anti-ulcer Agents
Dose-response Relationship, Drug
Plant Components, Aerial
Plant Extracts
Rats, Wistar
Stomach Ulcer
Rights: fechado
Identifier DOI: 10.1016/j.fitote.2007.07.003
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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