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Type: Artigo de periódico
Title: Usefulness Of Fsh Measurements For Determining Menopause In Long-term Users Of Depot Medroxyprogesterone Acetate Over 40 Years Of Age.
Author: Juliato, Cassia Teatin
Fernandes, Arlete
Marchi, Nadia Maria
Castro, Sara
Olivotti, Bruna
Bahamondes, Luis
Abstract: To assess the usefulness of follicle-stimulating hormone (FSH) measurements for determining menopause in 40-55-year-old users of depot medroxyprogesterone acetate (DMPA). FSH levels were measured in 355 blood samples from 82 amenorrheic women during an 18-month period. Blood was collected every 90 days immediately prior to DMPA administration. Using FSH values>35 mIU/mL as being in the post menopausal range, 32 women (39.0%) presented at least one FSH measurement in the postmenopausal range and 14 of them (43.7%) had more than one elevated FSH measurement and were considered postmenopausal. In five users (15.6%), only the last FSH measurement was within the postmenopausal range, and in 13 women (40.6%), FSH returned to normal values following one measurement that was within the postmenopausal range. The menopausal status in DMPA users in amenorrhea should be determined based on at least two consecutive high FSH evaluations, since, as shown here, 40.6% of the women with high FSH had a low FSH in the subsequent determination. FSH measurements should be done only in women>or=50 years old because there is a greater possibility of being in postmenopause. However, we do not recommend the interruption of DMPA use prior to the quantification of FSH.
Subject: Adult
Contraceptive Agents, Female
Follicle Stimulating Hormone
Medroxyprogesterone Acetate
Prospective Studies
Reference Values
Rights: fechado
Identifier DOI: 10.1016/j.contraception.2007.06.005
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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