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Type: Artigo de periódico
Title: Electrochemical And Spectroscopic Characterization Of The Interaction Between Dna And Cu(ii)-naringin Complex.
Author: Mello, Lucilene D
Pereira, Regina M S
Sawaya, Alexandra C H F
Eberlin, Marcos N
Kubota, Lauro T
Abstract: In this work the interaction of DNA and the flavonoid-transition metal complex (Cu(II)-naringin complex) is characterized. The interaction was evaluated by using electrochemical ssDNA- and dsDNA-based biosensors and the results were supported by UV, CD and (1)H NMR data. In the electrochemical method, changes in the oxidation peak of the guanine and adenine bases obtained by square wave voltammetry (SWV) showed evidence of the interaction. The variations of the spectroscopic characteristics of DNA and Cu(II)-naringin complex in aqueous medium demonstrated that the predominant interaction mode may be by intercalation. Cu(II)-naringin complex interacts to dsDNA probably via N(7) of guanine site.
Subject: Adenine
Biosensing Techniques
Circular Dichroism
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Tandem Mass Spectrometry
Citation: Journal Of Pharmaceutical And Biomedical Analysis. v. 45, n. 5, p. 706-13, 2007-Dec.
Rights: fechado
Identifier DOI: 10.1016/j.jpba.2007.08.007
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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