Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197453
Type: Artigo de periódico
Title: Anaemia In Patients With Cancer: Role Of Inflammatory Activity On Iron Metabolism And Severity Of Anaemia.
Author: Jacober, M L V
Mamoni, R L
Lima, C S P
Dos Anjos, B L
Grotto, H Z W
Abstract: Hepcidin has been proposed as an important factor in the pathogenesis of the anaemia of chronic disease (ACD). The aim of this study was to assess the relationship between anaemia and inflammatory activity in patients with solid tumours. Patients were classified as having iron deficiency anaemia (IDA) (hypoferremia and hypoferretinemia), ACD (hypoferremia, normal or increased serum ferritin) and anaemia related to cancer (ARC) (no abnormalities in iron status). Serum pro-hepcidin, IL-6, C-reactive protein (CRP) and iron status parameters were measured using commercial kits. CRP and IL-6 levels were significantly higher in patients with ACD when compared to IDA, ARC and non anaemic patients (P < 0.005). Serum pro-hepcidin levels were not different among all studied groups (P = 0.138). A negative correlation was observed between haemoglobin and serum ferritin, CRP and IL-6 levels only in group of ACD. Serum pro-hepcidin concentrations were not correlated with degree of anaemia or iron metabolism parameters. According to our results the inflammatory activity represented by high levels of IL-6 and CRP are involved in the pathogenesis of ACD, probably due to the action of inflammation on iron metabolism, but not in ARC. It was not possible to demonstrate a significant effect of pro-hepcidin on the anaemia in cancer patients.
Subject: Adult
Aged
Aged, 80 And Over
Anemia
Anemia, Iron-deficiency
Antimicrobial Cationic Peptides
C-reactive Protein
Case-control Studies
Female
Hepcidins
Humans
Inflammation
Interleukin-6
Iron
Male
Middle Aged
Neoplasms
Severity Of Illness Index
Citation: Medical Oncology (northwood, London, England). v. 24, n. 3, p. 323-9, 2007.
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/17873309
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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