Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197419
Type: Artigo de periódico
Title: Partial Internal Biliary Diversion Through A Cholecystojejunocolonic Anastomosis--a Novel Surgical Approach For Patients With Progressive Familial Intrahepatic Cholestasis: A Preliminary Report.
Author: Bustorff-Silva, Joaquim
Sbraggia Neto, Lourenço
Olímpio, Hugo
de Alcantara, Roberta Vacari
Matsushima, Erica
De Tommaso, Adriana Maria Alves
Brandão, Maria Angela Bellomo
Hessel, Gabriel
Abstract: The purpose of the study was to describe the initial experience with a novel approach to the surgical treatment of progressive familial intrahepatic cholestasis (PFIC), avoiding the creation of a permanent stoma. Two teenaged patients, aged 15 and 17 years, underwent partial internal biliary diversion to treat uncontrollable pruritus associated with PFIC. The surgical technique involved the creation of an isolated jejunal conduit, anastomosed proximally in a terminolateral fashion to the gallbladder and distally to the ascending colon. This operation combines the advantages of partially diverting the biliary flow from the enterohepatic cycle, avoiding an external biliary fistula. In one of the patients, this technique was used as a primary procedure, whereas in the other, a previous partial external diversion was converted to an internal diversion. Both patients had complete resolution of their pruritus and normalization of hepatic laboratory tests. One of the patients developed a mild choleretic diarrhea that can be controlled with eventual use of cholestyramine. No complications were observed related to this operation. Biliary diversion appears to be a very attractive surgical option for the treatment of PFIC in children with a normal gallbladder. Long-term follow-up is necessary to evaluate late results and eventual complications of this approach.
Subject: Adolescent
Anastomosis, Surgical
Cholestasis, Intrahepatic
Colon
Disease Progression
Female
Gallbladder
Genetic Predisposition To Disease
Humans
Jejunum
Male
Rights: fechado
Identifier DOI: 10.1016/j.jpedsurg.2007.03.029
Address: http://www.ncbi.nlm.nih.gov/pubmed/17706492
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_17706492.pdf82.29 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.