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Type: Artigo de periódico
Title: Expression Of Peroxiredoxin I In Plasma Cells Of Oral Inflammatory Diseases.
Author: Demasi, Ana P D
Ceratti, Daniela
Furuse, Cristiane
Cury, Patrícia
Junqueira, José L C
Araújo, Vera C
Abstract: The participation of reactive oxygen species (ROS) in the immune response, both as pathogen killers and as mediators of signaling pathways, is well established. However, little is known about the enzymes responsible for ROS elimination in immune cells. Peroxiredoxin I (PrdxI) is a multifunctional enzyme that exhibits thioredoxin-dependent peroxidase activity. It has been described as a major hydrogen peroxide (H(2)O(2))-inducible protein in mouse peritoneal macrophages. In order to characterize its participation in the antioxidant defense of inflammatory/immune cells in greater detail, we evaluated its expression at sites of the oral cavity affected by inflammatory disorders induced by different agents (infectious, chemical, mechanical or tumor). In this study we demonstrated, by immunohistochemistry, that PrdxI is expressed in plasma cells, but not in B lymphocytes, regardless of the inflammation-inducing agent. We suggest that PrdxI induction could be considered a crucial part of the cellular adaptive response to the B-cell differentiation process to cope with the additional H(2)O(2) associated with massive disulfide bond formation during immunoglobulin folding in the endoplasmic reticulum of plasma cells. PrdxI could diminish the tissue damage that accompanies inflammation.
Subject: B-lymphocytes
Carcinoma, Squamous Cell
Gingival Hyperplasia
Mouth Neoplasms
Plasma Cells
Rights: fechado
Identifier DOI: 10.1111/j.1600-0722.2007.00462.x
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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