Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197388
Type: Artigo de periódico
Title: High-performance Liquid Chromatographic Separation Of Rolipram, Bupivacaine And Omeprazole Using A Tartardiamide-based Stationary Phase Influence Of Flow Rate And Temperature On The Enantioseparation.
Author: da Silva Junior, Ivanildo José
Sartor, João Paulo
Rosa, Paulo César Pires
de Veredas, Vinícius
Barreto Júnior, Amaro Gomes
Santana, Cesar Costapinto
Abstract: Chromatographic separation of the chiral drugs rolipram, bupivacaine and omeprazole on a tartardiamide-based stationary phase commercially named Kromasil CHI-TBB is shown in this work. The effect of temperature on the chromatographic separation of the chiral drugs using the Kromasil CHI-TBB stationary phase was determined quantitatively so as to contribute toward the design for the racemic mixtures of the named compound by using chiral columns. A decrease in the retention and selectivity factors was observed, when the column temperature increased. Van't Hoff plots provided the thermodynamic data. The variation of the thermodynamic parameters enthalpy and entropy are clearly negative meaning that the separation is enthalpy controlled.
Subject: Algorithms
Anion Exchange Resins
Bupivacaine
Chemistry, Physical
Chromatography, High Pressure Liquid
Chromatography, Ion Exchange
Models, Chemical
Molecular Structure
Omeprazole
Physicochemical Phenomena
Rolipram
Stereoisomerism
Tartrates
Temperature
Thermodynamics
Rights: fechado
Identifier DOI: 10.1016/j.chroma.2007.07.008
Address: http://www.ncbi.nlm.nih.gov/pubmed/17645885
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_17645885.pdf431.99 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.