Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197272
Type: Artigo de periódico
Title: Expressions Of The Vla-4, Lfa-1 And Mac-1 Integrins In Eosinophil Migration In A Case Of Chronic Eosinophilic Leukaemia.
Author: Lima, Carmen S P
Franco-Penteado, Carla F
Canalli, Andreia A
Conran, Nicola
Lorand-Metze, Irene
Costa, Fernando F
Ferreira, Heloisa H A
Abstract: Migration of eosinophil (Eo) into tissues is a hallmark of chronic eosinophilic leukaemia (CEL), but the exact mechanism involved in cell migration is unknown. We report on a patient with CEL who presented high expressions of VLA-4, LFA-1 and Mac-1 integrins on the Eo surface, increased chemotaxis of Eo to eotaxin, decreased chemotaxis of Eo after inhibition of the cyclic guanosine monophosphate (cGMP), and a high level of intracellular cGMP. These findings suggest that an upregulation of expression of these integrins on Eo surface and a high intracellular level of cGMP may be involved in the increased Eo migration observed in our CEL patient. However, the definitive roles of these molecules in the proliferation and migration of Eo in CEL disease require wider confirmation by analysis of additional patients with the disease.
Subject: Cell Movement
Chemotactic Factors, Eosinophil
Chemotaxis, Leukocyte
Chronic Disease
Eosinophils
Female
Humans
Hypereosinophilic Syndrome
Integrin Alpha4beta1
Lymphocyte Function-associated Antigen-1
Macrophage-1 Antigen
Middle Aged
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2006.07.025
Address: http://www.ncbi.nlm.nih.gov/pubmed/16956660
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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