Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197271
Type: Artigo de periódico
Title: Protective Effect Of Collagen Derivates On The Ulcerative Lesions Caused By Oral Administration Of Ethanol.
Author: Castro, G A
Sgarbieri, V C
Carvalho, J E
Tinti, S V
Possenti, A
Abstract: The protective effect of beef and pig collagen hydrolysates and their fractions were tested as anti-ulcerogenic agents in rats (weighing 250-350 g) against ulcerative lesions caused by ethanol. Beef and pig collagen hydrolysates were fractionated by ultrafiltration into different molecular weight fractions. The protocol employed a negative and a positive control and a single dose of the experimental samples given by intragastric intubation. The beef collagen did not present a dose-response correlation in the ethanol model, whereas pig collagen showed a logarithmic dose-response relationship. Beef collagen hydrolysate decreased the ulcerative lesion index of 55% versus a 61% decrease for pig collagen hydrolysate at the same dosage (750 mg/kg of body weight). No significant differences were found (P > .05) between the hydrolysates and their fractions.
Subject: Animals
Anti-ulcer Agents
Carbenoxolone
Cattle
Collagen
Dose-response Relationship, Drug
Ethanol
Hydrolysis
Male
Rats
Rats, Wistar
Stomach Ulcer
Swine
Rights: fechado
Identifier DOI: 10.1089/jmf.2006.262
Address: http://www.ncbi.nlm.nih.gov/pubmed/17472480
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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