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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleLinkage Study Of Voltage-gated Potassium Channels In Familial Mesial Temporal Lobe Epilepsy.pt_BR
dc.contributor.authorMaurer-Morelli, Cláudia Viannapt_BR
dc.contributor.authorMarchesini, Rafael Bregliopt_BR
dc.contributor.authorSecolin, Rodrigopt_BR
dc.contributor.authorSantos, Neide Ferreirapt_BR
dc.contributor.authorKobayashi, Elianept_BR
dc.contributor.authorCendes, Fernandopt_BR
dc.contributor.authorLopes-Cendes, Isciapt_BR
unicamp.authorCláudia Vianna Maurer-Morelli, Department of Medical Genetics, Universidade Estadual de Campinas, Rua Tessalia Vieira de Camargo 126, 13084-971 Campinas, SP, Brazil.pt_BR
unicamp.author.externalRafael Breglio Marchesini,pt
unicamp.author.externalRodrigo Secolin,pt
unicamp.author.externalNeide Ferreira Santos,pt
unicamp.author.externalEliane Kobayashi,pt
unicamp.author.externalFernando Cendes,pt
unicamp.author.externalIscia Lopes-Cendes,pt
dc.subjectAtrophypt_BR
dc.subjectEpilepsy, Temporal Lobept_BR
dc.subjectGenetic Linkagept_BR
dc.subjectGenotypept_BR
dc.subjectHippocampuspt_BR
dc.subjectHumanspt_BR
dc.subjectPotassium Channels, Voltage-gatedpt_BR
dc.description.abstractVoltage-gated potassium channels (VGKCs) play a critical role in the regulation of neuronal excitability and have been implicated in some types of epilepsies. Recently, autoimmune limbic encephalitis (LE) was associated with antibodies against VGKC. In addition, patients with LE showed partial epilepsy and increased T2 signal abnormalities in limbic structures. We have reported familial mesial temporal lobe epilepsy (FMTLE) associated with hippocampal atrophy (HA) and other signs of mesial temporal sclerosis detected by magnetic resonance imaging (MRI). In order to investigate whether VGKC may be associated to HA present in FMTLE, we perform linkage study in these candidate genes. Seventy-three microsatellites markers were genotyped in different human autosomal chromosome. Two-point LOD scores did not show evidence for linkage with any of the microsatellite markers genotyped (Zmax ranging from 0.11to-9.53 at theta=0.00). In the present study, linkage data showed no evidence that VGKC are involved in the determination of HA in FMTLE.en
dc.relation.ispartofArquivos De Neuro-psiquiatriapt_BR
dc.relation.ispartofabbreviationArq Neuropsiquiatrpt_BR
dc.date.issued2007-Marpt_BR
dc.identifier.citationArquivos De Neuro-psiquiatria. v. 65, n. 1, p. 20-3, 2007-Mar.pt_BR
dc.language.isoengpt_BR
dc.description.volume65pt_BR
dc.description.firstpage20-3pt_BR
dc.rightsabertopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0004-282Xpt_BR
dc.identifier.doipt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/17420821pt_BR
dc.date.available2015-11-27T13:09:59Z-
dc.date.accessioned2015-11-27T13:09:59Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:09:59Z (GMT). No. of bitstreams: 1 pmed_17420821.pdf: 331979 bytes, checksum: 29acceb6498effc34342cbf2afcb0bd7 (MD5) Previous issue date: 2007en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197238-
dc.identifier.idPubmed17420821pt_BR
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