Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197194
Type: Artigo de periódico
Title: Experimental Endocrine Therapies Promote Epithelial Cytodifferentiation And Ciliogenesis In The Gerbil Female Prostate.
Author: Santos, Fernanda Cristina Alcântara
Falleiros-Júnior, Luiz Roberto
Corradi, Lara Silvia
Vilamaior, Patricia Simone Leite
Taboga, Sebastião Roberto
Abstract: The incidence of ciliated cells in the prostate gland of the female gerbil (Meriones unguiculatus) is uncommon and apparently becomes more frequent during androgen (testosterone cypionate) and anti-estrogen (letrozole) endocrine therapies. To evaluate the effects of such drug therapies on the induction of ciliogenesis in the glandular epithelium of female prostate glands, adult female gerbils aged 90 days were treated for 14 days with testosterone and letrozole after which their prostate glands were removed for histological, ultrastructural, and serological analyses. The cytodifferentiation of the ciliated phenotype in the alveolar epithelium became more frequent after both the testosterone and the letrozole treatments. The ciliogenesis phenomenon of the epithelial cells in the prostate gland of female gerbils thus appears to be induced by variations in the increase of androgen levels.
Subject: Animals
Body Weight
Cell Differentiation
Cilia
Epithelial Cells
Female
Gerbillinae
Gonadal Steroid Hormones
Hormone Replacement Therapy
Male
Nitriles
Organ Size
Prostate
Testosterone
Triazoles
Rights: fechado
Identifier DOI: 10.1007/s00441-007-0381-y
Address: http://www.ncbi.nlm.nih.gov/pubmed/17347814
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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