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Type: Artigo de periódico
Title: Human Papillomavirus (hpv) Infections As Risk Factors For Cytological And Histological Abnormalities In Baseline Pap Smear-negative Women Followed-up For 2 Years In The Lams Study.
Author: Gontijo, Renata C
Derchain, Sophie F M
Roteli-Martins, Cecilia
Bragança, Joana F
Sarian, Luis O
Morais, Sirlei S
Maeda, Marina Yoshie Sakamoto
Longatto-Filho, Adhemar
Syrjänen, Kari J
Abstract: To assess the role of HPV as determinant of the incident cytological abnormalities (SIL) and cervical lesions (CIN) during a 24-month follow-up of baseline PAP smear-negative subgroup of women included in the Latin American Screening study (LAMS). A group of 365 women with normal Pap smear and negative or positive high-risk Hybrid Capture II test were prospectively followed-up for 24 months at Campinas and São Paulo (Brazil). The incidence rate (IR) and risk ratio (RR and 95% CI) of developing cytological or histological abnormality during the follow-up was calculated for HPV-negative and HPV-positive women. During the 12-month follow-up, women HPV-positive at baseline had developed a significantly higher rate of incident LSIL (IR=3.5%, RR=1.4; 95% CI 1.1-1.7) and HSIL (IR=0.7%, RR=1.5; 95% CI 1.4-1.7) abnormality. For HSIL, the IR increased to 2.1% and the RR increased to 1.7 (95% CI 1.5-1.9) among those followed for 24 months. Similarly, women with positive HPV tests were at a higher risk of developing CIN 2-3 (IR=2.6%, RR=1.5; 95% CI 1.4-1.6) during the first 12 months of follow-up, and for those followed for 24 months, this RR increased further to 1.7 (95% CI 1.5-1.9) although the IR was 0.7%. Oncogenic HPV infections comprise a significant risk factor for incident cervical abnormalities, and HPV test is a useful adjunct to cytology in detecting the high-risk patients among baseline PAP smear-negative women.
Subject: Adolescent
Cervical Intraepithelial Neoplasia
Middle Aged
Papanicolaou Test
Papillomavirus Infections
Risk Factors
Uterine Cervical Neoplasms
Vaginal Smears
Citation: European Journal Of Obstetrics, Gynecology, And Reproductive Biology. v. 133, n. 2, p. 239-46, 2007-Aug.
Rights: fechado
Identifier DOI: 10.1016/j.ejogrb.2006.05.012
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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