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Type: Artigo de periódico
Title: Dual Mechanism Of Mangiferin Protection Against Iron-induced Damage To 2-deoxyribose And Ascorbate Oxidation.
Author: Pardo-Andreu, Gilberto Lázaro
Delgado, René
Núñez-Sellés, Alberto J
Vercesi, Anibal E
Abstract: We studied mangiferin effects on the degradation of 2-deoxyribose induced by Fe(III)-EDTA/citrate plus ascorbate, in relation to ascorbate oxidation (measured at 265 nm). Results revealed that mangiferin was equally effective in preventing degradation of both 15 and 1.5 mM 2-deoxyribose. At a fixed Fe(III) concentration, increasing the concentration of ligands (either EDTA or citrate) caused a significant reduction in the protective effects of mangiferin. Interestingly, mangiferin strongly stimulated Fe(III)-EDTA ascorbate oxidation, but inhibited it when citrate was used as iron co-chelator. Mangiferin stimulated O2 consumption due to Fe(II) (formed by Fe(III) ascorbate reduction) autoxidation when the metal ligand was EDTA, but inhibited it when citrate was used. These results suggest that mangiferin removes iron from citrate, but not from EDTA, forming an iron-mangiferin complex that cannot induce ascorbate oxidation effectively, thus inhibiting iron-mediated oxyradical formation. Taken together, these results indicate that mangiferin works mainly by a mechanism different from the classical hydroxyl radical scavengers, keeping iron in its ferric form, by complexing Fe(III), or stimulating Fe(II) autoxidation.
Subject: Antioxidants
Ascorbic Acid
Edetic Acid
Ferric Compounds
Iron Chelating Agents
Models, Chemical
Citation: Pharmacological Research : The Official Journal Of The Italian Pharmacological Society. v. 53, n. 3, p. 253-60, 2006-Mar.
Rights: fechado
Identifier DOI: 10.1016/j.phrs.2005.06.006
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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