Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197125
Type: Artigo de periódico
Title: Subdermal Implants Of Poly(l-lactic Acid) With Plasticizer: An Ultrastructural Study In Rats.
Author: Silva, D R M
Joazeiro, P P
Duek, E A R
Alberto-Rincon, M C
Abstract: Poly(L-lactic acid) (PLLA) membranes containing 7% triethylcitrate plasticizer were implanted in the subcutaneous tissue of rats, and the cellular reaction was evaluated over a period of 2-180 days. The samples were processed for conventional transmission electron microscopy. Polymorphonuclear-type cells and a fibrin network were seen within membrane pores 2 days after implantation. In subsequent samples, there was cellular infiltration, which consisted mainly of fibroblasts, macrophages and multinuclear giant cells embedded in an abundant extracellular matrix containing a network of collagen fibers and blood vessels. At 90 and 180 days after implantation, a high density of voluminous phagocytic cells with a large number of endocytic polymer fragments within their cytoplasm was seen. These results show that PLLA membranes can support connective tissue proliferation and remodeling, which are important properties for successful bio-protheses.
Subject: Animals
Female
Implants, Experimental
Lactic Acid
Microscopy, Electron, Transmission
Plasticizers
Polymers
Rats
Rats, Wistar
Skin
Citation: Journal Of Biomaterials Science. Polymer Edition. v. 17, n. 1-2, p. 177-85, 2006.
Rights: fechado
Address: http://www.ncbi.nlm.nih.gov/pubmed/16411607
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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