Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197024
Type: Artigo de periódico
Title: In Vitro Studies On The Release Of Isoniazid Incorporated In Poly(epsilon-caprolactone).
Author: Durán, N
De Oliveira, A F
De Azevedo, M M M
Abstract: A polymeric micro- and nanosphere formulation using poly (epsilon-caprolactone) (PCL) to entrap an antituberculosis drug, isoniazid (INH), was developed and characterized. The microspheres were prepared by a solvent evaporation method using ethyl acetate, PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. The nanospheres were prepared by a spontaneous emulsification solvent diffusion method using 40% ethanol in acetone (v/v), PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. After freeze-drying, these systems were characterized by scanning electron microscopy (SEM), particle size analysis, determination of entrapped INH content, in vitro INH release and brine shrimp toxicity bioassay.
Subject: Animals
Antibiotics, Antitubercular
Artemia
Caproates
Delayed-action Preparations
Drug Compounding
Drug Delivery Systems
Isoniazid
Lactones
Microspheres
Nanotubes
Particle Size
Polymers
Toxicity Tests
Rights: fechado
Identifier DOI: 10.1179/joc.2006.18.5.473
Address: http://www.ncbi.nlm.nih.gov/pubmed/17127222
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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