Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Hemodynamic Effects Of Bupropion In Anesthetized Dogs.
Author: Paganelli, Maria Ondina
Tanus-Santos, José Eduardo
Sabha, Maricene
do Prado, Joaquim Francisco
Chaud, Marco Vinicíus
Martins, Luís Cláudio
Moreno, Heitor
Abstract: Bupropion is a non-nicotinic drug used in smoking cessation therapy. However, its acute effects remain unclear. In this study, we investigated the effects of bupropion on hemodynamic parameters in pentobarbital-anesthetized mongrel dogs. Bupropion administered either in bolus injections (3 or 6 mg/kg, i.v.) or in cumulative doses of 0.01, 0.1, 1, 3 and 10 mg/kg showed, in both studies, a significant increase of mean pulmonary arterial pressure and pulmonary vascular resistance index. These results show that bupropion can elevate the pulmonary pressure. Further investigations should be done to test this effect in smokers with chronic obstructive pulmonary disease.
Subject: Anesthesia, Intravenous
Antidepressive Agents, Second-generation
Blood Pressure
Dose-response Relationship, Drug
Pulmonary Circulation
Time Factors
Vascular Resistance
Rights: fechado
Identifier DOI: 10.1016/j.ejphar.2005.11.019
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_16376873.pdf239.5 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.