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Type: Artigo de periódico
Title: Stimulation Of Soluble Guanylyl Cyclase By Bay 41-2272 Relaxes Anococcygeus Muscle: Interaction With Nitric Oxide.
Author: Teixeira, Cleber E
Priviero, Fernanda B M
Claudino, Mário A
Baracat, Juliana S
De Nucci, Gilberto
Webb, R Clinton
Antunes, Edson
Abstract: The compound BAY 41-2272 stimulates the soluble guanylyl cyclase in a nitric oxide (NO)-independent manner. We have investigated the potency and efficacy of BAY 41-2272 in the rat anococcygeus muscle, as well as the effects of BAY 41-2272 on NO-mediated anococcygeus relaxations. BAY 41-2272 (0.01-10 microM) potently relaxed precontracted anococcygeus muscle strips, with a pEC(50) value of 6.44 +/- 0.03 and maximum response of 100 +/- 2%. The soluble guanylyl cyclase inhibitor 1H-[1,2,4]-oxidiazolo[4,3-a] quinoxalin-1-one (ODQ, 1 microM) and the NO inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME, 100 microM) caused significant rightward shifts in the concentration-response curves to BAY 41-2272. The phosphodiesterase type-5 inhibitor tadalafil (0.1 microM) markedly enhanced the relaxations evoked by BAY 41-2272. In addition, BAY 41-2272 increased the duration of nitrergic relaxations by approximately 55%. The relaxations induced by glyceryl trinitrate were also significantly potentiated by BAY 41-2272. In conclusion, BAY 41-2272 interacts with endogenous and exogenous NO causing a potent relaxation of rat anococcygeus muscle.
Subject: Animals
Cyclic Amp
Cyclic Gmp
Dose-response Relationship, Drug
Drug Synergism
Electric Stimulation
Enzyme Activation
Enzyme Inhibitors
Guanylate Cyclase
Muscle Contraction
Muscle Relaxation
Muscle, Smooth
Ng-nitroarginine Methyl Ester
Nitric Oxide
Nitric Oxide Donors
Nitric Oxide Synthase
Rats, Wistar
Receptors, Cytoplasmic And Nuclear
Citation: European Journal Of Pharmacology. v. 530, n. 1-2, p. 157-65, 2006-Jan.
Rights: fechado
Identifier DOI: 10.1016/j.ejphar.2005.11.015
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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