Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196971
Type: Artigo de periódico
Title: Reticulocyte Evaluation In Alpha(+)-thalassemia.
Author: Krügner, F
Zaccariotto, T R
Rosim, E T
Costa, F F
Grotto, H Z W
Sonati, M F
Abstract: Although it is almost certain that alpha(+)-thalassemia protects against malaria, the mechanisms for that are still unknown. It has been suggested that an increased number of young circulating red blood cells in alpha(+)-thalassemic children, as a result of some degree of ineffective erythropoiesis, could be related to the high frequencies of the alpha(+)-thalassemic allele in malaria endemic areas. Reticulocyte evaluation in this condition, however, has been poorly performed so far. Our objective was to determine the reticulocyte number and maturation degree, in addition to the soluble transferrin receptor and serum erythropoietin levels, in alpha(+)-thalassemia heterozygotes, comparing them with normal alpha-genotype controls. One hundred twenty-one alpha(+)-thalassemia carriers (-alpha(3.7)/alphaalpha) and 249 controls (alphaalpha/alphaalpha), all of them with normal serum ferritin levels, were subclassified according to age (1-5, 6-10, 11-15, 16-20, and over 20 years old). Reticulocyte analyzes were carried out by flow cytometry and sTfR and s-Epo levels determined by immunonephelometry and chemiluminescence, respectively. The comparisons did not show any significant difference between thalassemics and controls regarding the reticulocyte parameters [percentages and absolute values, P = 0.2643 and 0.5421; high, medium, and low maturation degree, P = 0.2579, 0.2196, and 0.4192; RET maturity index (RMI), P = 0.2471, respectively], as well as the s-Epo levels (P = 0.5711). The sTfR concentrations were higher in the thalassemic group (P = 0.0001), but statistical significance was due only to the 1-5 and over 20 subgroups (P = 0.0082 and 0.0436, respectively). The results found here are compatible with a compensated erythropoiesis and do not confirm the hypothesis mentioned above.
Subject: Adolescent
Adult
Brazil
Child
Child, Preschool
Erythropoiesis
Erythropoietin
Female
Ferritins
Flow Cytometry
Heterozygote
Humans
Infant
Malaria
Male
Nephelometry And Turbidimetry
Receptors, Transferrin
Reticulocyte Count
Reticulocytes
Alpha-thalassemia
Rights: fechado
Identifier DOI: 10.1002/ajh.20487
Address: http://www.ncbi.nlm.nih.gov/pubmed/16369954
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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