Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196961
Type: Artigo de periódico
Title: Natural Compounds As A Source Of Protein Tyrosine Phosphatase Inhibitors: Application To The Rational Design Of Small-molecule Derivatives.
Author: Ferreira, Carmen V
Justo, Giselle Z
Souza, Ana C S
Queiroz, Karla C S
Zambuzzi, William F
Aoyama, Hiroshi
Peppelenbosch, Maikel P
Abstract: Reversible phosphorylation of tyrosine residues is a key regulatory mechanism for numerous cellular events. Protein tyrosine kinases and protein tyrosine phosphatases (PTPs) have a pivotal role in regulating both normal cell physiology and pathophysiology. Accordingly, deregulated activity of both protein tyrosine kinases and PTPs is involved in the development of numerous congenitically inherited and acquired human diseases, prompting obvious pharmaceutical and academic research interest. The development of compound libraries with higher selective PTP inhibitory activity has been bolstered by the realization that many natural products have such activity and thus are interesting biologically lead compounds, which properties are widely exploited. In addition, more rational approaches have focused on the incorporation of phosphotyrosine mimetics into specific peptide templates (peptidomimetic backbones). Additional factors furthering discovery as well as therapeutic application of new bioactive molecules are the integration of functional genomics, cell biology, structural biology, drug design, molecular screening and chemical diversity. Together, all these factors will lead to new avenues to treat clinical disease based on PTP inhibition.
Subject: Animals
Biological Products
Drug Design
Enzyme Inhibitors
Humans
Molecular Structure
Protein Tyrosine Phosphatases
Rights: fechado
Identifier DOI: 10.1016/j.biochi.2006.08.007
Address: http://www.ncbi.nlm.nih.gov/pubmed/17010496
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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