Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196941
Type: Artigo de periódico
Title: Enamel Matrix Derivative Versus Guided Tissue Regeneration In The Presence Of Nicotine: A Histomorphometric Study In Dogs.
Author: Pimentel, Suzana Peres
Sallum, Antonio Wilson
Saldanha, Juliana Bezerra
Casati, Márcio Zaffalon
Nociti, Francisco H
Sallum, Enilson A
Abstract: The goal of this histometric study was to compare the healing process of dehiscence-type defects treated by enamel matrix derivative (EMD) or guided tissue regeneration (GTR) under the effect of nicotine in the dog model. Eight mongrel dogs were used. Buccal osseous dehiscences were surgically created on the mesial roots of the mandibular third and fourth pre-molars. The defects were exposed to plaque accumulation for 3 months. After this period, the defects were randomly assigned to one of the treatments: open flap debridement (OFD), EMD or GTR with a resorbable membrane. During 4 months, the dogs received subcutaneous administration of nicotine (2 mg/kg twice a day with a 12 h interval between the applications). After this period, the animals were killed and the blocks were processed. The histometric parameters evaluated included gingival recession, epithelial length, connective tissue adaptation, new cementum and new bone. A superior length of new cementum was observed in the sites treated by EMD in comparison with OFD (p< or =0.05). No statistically significant differences were observed between GTR and the other groups. In the presence of nicotine, EMD may promote more new cementum formation than OFD while GTR failed to provide a significant difference.
Subject: Absorbable Implants
Alveolar Bone Loss
Alveolar Process
Animals
Biocompatible Materials
Connective Tissue
Cotinine
Debridement
Dental Cementum
Dental Enamel Proteins
Dental Plaque
Disease Models, Animal
Dogs
Epithelial Attachment
Gingival Recession
Guided Tissue Regeneration, Periodontal
Injections, Subcutaneous
Membranes, Artificial
Nicotine
Nicotinic Agonists
Random Allocation
Surgical Flaps
Wound Healing
Rights: fechado
Identifier DOI: 10.1111/j.1600-051X.2006.00989.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/16970622
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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