Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196924
Type: Artigo de periódico
Title: Characterization And Outcome Of Uveitis In 350 Patients With Spondyloarthropathies.
Author: Sampaio-Barros, Percival D
Conde, Roseneide A
Bonfiglioli, Rubens
Bértolo, Manoel B
Samara, Adil M
Abstract: This retrospective study analyzed 350 patients with the diagnosis of spondyloarthropathies (SPA) (207 with ankylosing spondylitis (AS), 80 with undifferentiated spondyloarthropathies (USPA) and 63 with psoriatic arthritis (PsA)) attended at a tertiary referral hospital for a minimum period of 5 years. All the patients presented complete clinical (axial and peripheral involvement, heel enthesopathies, extra-articular manifestations) and radiologic (sacroiliac, lumbar, dorsal and cervical spine) evaluation. HLA-B27 and respective alleles were searched. These data were compared with the occurrence of uveitis during the follow-up of the SPA patients. Thirty AS patients (14.5%) presented 55 episodes of acute anterior uveitis; there was statistical association between uveitis and juvenile-onset AS (P = 0.0094) and achillean (P = 0.0003) and plantar (P = 0.0067) enthesopathies; one AS patient presented a single episode of posterior uveitis, associated to tuberculosis. Seven USPA patients (8.8%) presented 13 episodes of acute anterior uveitis; it was not observed statistical association with any variable; one patient presented a single episode of posterior uveitis, associated to toxoplasmosis. Five HLA-B27 positive PsA patients (8%) presented 13 episodes of acute anterior uveitis. All the 26 positive HLA-B27 SPA patients with anterior uveitis tested for the HLA-B27 alleles were HLA-B*2705. No patient presented ophthalmologic severe sequelae of the anterior uveitis. Concluding, anterior uveitis was associated to the juvenile onset of the disease and to the enthesophatic involvement of the lower limbs in AS patients. The HLA-B*2705 allele was predominant in the anterior uveitis patients, whilst posterior uveitis was rare and associated to infectious disease.
Subject: Adolescent
Adult
Alleles
Arthritis, Psoriatic
Female
Hla-b Antigens
Hla-b27 Antigen
Humans
Male
Spondylarthropathies
Spondylitis, Ankylosing
Treatment Outcome
Uveitis
Rights: fechado
Identifier DOI: 10.1007/s00296-006-0203-7
Address: http://www.ncbi.nlm.nih.gov/pubmed/16957887
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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