Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196892
Type: Artigo de periódico
Title: Prophylactic Administration Of Withania Somnifera Extract Increases Host Resistance In Listeria Monocytogenes Infected Mice.
Author: Teixeira, Silvia T
Valadares, Marize C
Gonçalves, Shirley A
de Melo, Adriana
Queiroz, Mary L S
Abstract: In this study, we demonstrated that Withania somnifera L. extract (WSE) protects mice from a lethal dose of Listeria monocytogenes when administered prophylactically at 100, 250 and 500 mg/kg for 10 days, with survival rates up to 30%. These doses also prevented the myelosuppression and the splenomegaly caused by a sublethal infection with L. monocytogenes, due to increased numbers of granulocyte-macrophage progenitors (CFU-GM) in the bone marrow. Investigation of the production of colony-stimulating factors (CSFs) revealed increased colony-stimulating activity (CSA) in the serum of normal and infected mice pre-treated with WSE. Further studies to investigate the levels of interferon-gamma (INF-gamma) and lymphocyte cell proliferation were undertaken. We observed dose-dependent increases in cell proliferation and in the levels of INF-gamma in mice infected with L. monocytogenes and treated with WSE. All together, our results suggest that WSE indirectly modulates immune activity and probably disengages Listeria-induced suppression of these responses by inducing a higher reserve of myeloid progenitors in the bone marrow, proliferation of lymphocytes and increased INF-gamma levels.
Subject: Animals
Cell Proliferation
Disease Models, Animal
Granulocyte-macrophage Colony-stimulating Factor
Interferon-gamma
Listeria Monocytogenes
Listeriosis
Lymphocytes
Male
Mice
Mice, Inbred Balb C
Plant Extracts
Spleen
Withania
Rights: fechado
Identifier DOI: 10.1016/j.intimp.2006.03.016
Address: http://www.ncbi.nlm.nih.gov/pubmed/16919825
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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