Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196880
Type: Artigo de periódico
Title: The Scn2a Gene Is Not A Likely Candidate For Familial Mesial Temporal Lobe Epilepsy.
Author: Maurer-Morelli, Cláudia Vianna
Secolin, Rodrigo
Marchesini, Rafael Breglio
Santos, Neide Ferreira
Kobayashi, Eliane
Cendes, Fernando
Lopes-Cendes, Iscia
Abstract: A transgenic mouse model carrying a mutation in the Scn2a gene showed chronic focal seizures associated with extensive cell loss and gliosis in the hippocampus, a similar phenotype found in familial mesial temporal lobe epilepsy (FMTLE). Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE.
Subject: Epilepsy, Temporal Lobe
Genetic Linkage
Humans
Microsatellite Repeats
Mutation
Nav1.2 Voltage-gated Sodium Channel
Nerve Tissue Proteins
Sclerosis
Sodium Channels
Temporal Lobe
Rights: fechado
Identifier DOI: 10.1016/j.eplepsyres.2006.06.016
Address: http://www.ncbi.nlm.nih.gov/pubmed/16914293
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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