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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleRisk Factors And Characteristics Of Ocular Complications, And Efficacy Of Autologous Serum Tears After Haematopoietic Progenitor Cell Transplantation.pt_BR
dc.contributor.authorLeite, S Cpt_BR
dc.contributor.authorde Castro, R Spt_BR
dc.contributor.authorAlves, Mpt_BR
dc.contributor.authorCunha, D Apt_BR
dc.contributor.authorCorrea, M E Ppt_BR
dc.contributor.authorda Silveira, L Apt_BR
dc.contributor.authorVigorito, A Cpt_BR
dc.contributor.authorde Souza, C Apt_BR
dc.contributor.authorRocha, E Mpt_BR
unicamp.authorS C Leite, Department of Ophthalmology & Otorhinolaryngology, State University of Campinas, (UNICAMP), Campinas, São Paulo, Brazil.pt_BR
unicamp.author.externalR S de Castro,pt
unicamp.author.externalM Alves,pt
unicamp.author.externalD A Cunha,pt
unicamp.author.externalM E P Correa,pt
unicamp.author.externalL A da Silveira,pt
unicamp.author.externalA C Vigorito,pt
unicamp.author.externalC A de Souza,pt
unicamp.author.externalE M Rocha,pt
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectAge Factorspt_BR
dc.subjectChildpt_BR
dc.subjectDry Eye Syndromespt_BR
dc.subjectFemalept_BR
dc.subjectHematopoietic Stem Cell Transplantationpt_BR
dc.subjectHumanspt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectOphthalmic Solutionspt_BR
dc.subjectRisk Factorspt_BR
dc.subjectSerumpt_BR
dc.description.abstractThe objective of the study was to evaluate the frequency and clinical characteristics of ocular complications and their risk factors, as well as autologous serum tears (AST) for the treatment of dry eye in these patients. Data from the files of 124 patients who had undergone allogeneic haematopoietic progenitor cell transplantation (HPCT) were evaluated. In addition, 33 HPCT patients were examined and their data were compared with controls. Analysis of tears and AST was performed. Dry eye manifestation occurred in 32% of patients and was positively correlated with age over 27 years (P = 0.05), peripheral blood progenitor cell transplant (P = 0.002), chronic graft-versus-host disease (P = 0.0027), and chronic or acute myeloid leukaemia (P = 0.001). Dry mouth and Schirmer test < 5 mm were predictive factors for dry eye in HPCT patients (P = 0.002 and odds ratio 3.9 and P = 0.007, odds ratio = 5.9, respectively). Microbiological analysis revealed that six of 11 AST samples were contaminated after 30 days of use. The present study supports the role of potential risk factors for ocular complications and key elements to detect alterations in the tear film from HPCT patients. In addition, AST contamination must be considered after longer periods of use.en
dc.relation.ispartofBone Marrow Transplantationpt_BR
dc.relation.ispartofabbreviationBone Marrow Transplant.pt_BR
dc.date.issued2006-Augpt_BR
dc.identifier.citationBone Marrow Transplantation. v. 38, n. 3, p. 223-7, 2006-Aug.pt_BR
dc.language.isoengpt_BR
dc.description.volume38pt_BR
dc.description.firstpage223-7pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0268-3369pt_BR
dc.identifier.doi10.1038/sj.bmt.1705426pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/16785864pt_BR
dc.date.available2015-11-27T13:05:33Z-
dc.date.accessioned2015-11-27T13:05:33Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:05:33Z (GMT). No. of bitstreams: 1 pmed_16785864.pdf: 120740 bytes, checksum: 6c83d604a802e61c69304326645dfcbc (MD5) Previous issue date: 2006en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196816-
dc.identifier.idPubmed16785864pt_BR
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