Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196797
Type: Artigo de periódico
Title: Effectiveness And Safety Of A New Vaginal Misoprostol Product Specifically Labeled For Cervical Ripening And Labor Induction.
Author: Cecatti, José Guilherme
Tedesco, Ricardo Porto
Pires, Helaine Maria Besteti
Calderon, Iracema Matos
Faúndes, Aníbal
Abstract: The purpose of this study was to evaluate the effectiveness and safety of misoprostol in two different formulations: vaginal tablets of 25 microg and one-eighth of a 200-microg oral tablet, also administered intravaginally, for cervical ripening and labor induction of term pregnancies with an indication for that. A single-blind, randomized, controlled clinical trial was carried out in 120 pregnant women who randomly received one of the two formulations. The main dependent variables were mode of delivery, need for additional oxytocin, time between beginning of induction and delivery, perinatal results, complications, and maternal side effects. Student's t, Mann-Whitney, chi2, Fisher's Exact, Wilcoxon and Kolmogorov-Smirnoff tests, as well as survival analysis, were used in the data analysis. There were no significant differences between the groups in terms of general characteristics, uterine contractility, and fetal well-being during labor, cesarean section rates, perinatal outcomes, or maternal adverse events. The mean time between the beginning of cervical ripening and delivery was 31.3 h in the vaginal tablet group and 30.1 h in the oral tablet group, a difference that was not statistically significant. The results showed that the 25-microg vaginal tablets of misoprostol were as effective and safe for cervical ripening and labor induction as the dose-equivalent fraction of 200-microg oral tablets.
Subject: Administration, Intravaginal
Adult
Cervical Ripening
Cervix Uteri
Female
Humans
Labor, Induced
Misoprostol
Oxytocics
Pilot Projects
Pregnancy
Pregnancy Outcome
Single-blind Method
Treatment Outcome
Rights: fechado
Identifier DOI: 10.1080/00016340500432580
Address: http://www.ncbi.nlm.nih.gov/pubmed/16752263
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_16752263.pdf76 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.