Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196792
Type: Artigo de periódico
Title: Lung Disease Features In Brazilian Children With Hiv Infection Before Haart Era.
Author: Toro, A A D C
Altemani, A A M
Zanardi, V A
Menezes, J R
da Silva, M N
Vilela, M M S
Abstract: Lower respiratory tract diseases are major causes of morbidity and mortality in HIV infected children. We studied the lung disease features associated with AIDS in children and adolescents, in an era of ineffective antiretroviral therapy, between January 1996 and October 1998. This prospective, descriptive, longitudinal and historical medical chart review included 48 vertically HIV infected patients, receiving mono or double antiretroviral therapy, who had developed pulmonary disease. Those who presented acute pneumonia were classified into group 1; radiological changes for >or=3 months into group 2; those from group 1 and 2 who underwent lung biopsy into group 3. A rapidly progressive clinical course was found in 70.7% of the children and 37.5% younger than 6 months old. Bacterial pneumonia was diagnosed in all patients. High resolution chest computer tomographic scans (HRCT) from 27 patients showed a reticulonodular pattern in 8, ground-glass in 3, reticular in 3, nodular in 3, airspace consolidation in 3, mediastinal adenopathy in 3, pulmonary air cystic in 2 and air-trapping in 1. In five patients the HRCT were normal. Histopathology revealed: lymphoid interstitial pneumonitis in 5 patients, pulmonary lymphoid hyperplasia in 9, tuberculosis in 1, interstitial pneumonia in 1, diffuse alveolar damage in 1. Two patients had Cryptococcus neoformans and Mycobacterium tuberculosis. We conclude that lung diseases were the major risk factor for high morbidity, and an invasive diagnostic procedure may clarify the main cause for similar radiologic images of infectious and non-infectious processes.
Subject: Anti-retroviral Agents
Brazil
Child
Female
Hiv Infections
Humans
Hyperplasia
Infectious Disease Transmission, Vertical
Longitudinal Studies
Lung
Lung Diseases, Interstitial
Lymphoid Tissue
Male
Necrosis
Pneumonia, Bacterial
Prospective Studies
Time Factors
Tuberculosis
Rights: fechado
Identifier DOI: 10.1093/tropej/fml019
Address: http://www.ncbi.nlm.nih.gov/pubmed/16735366
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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