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|Type:||Artigo de periódico|
|Title:||Mitochondrial Ca2+ Transport, Permeability Transition And Oxidative Stress In Cell Death: Implications In Cardiotoxicity, Neurodegeneration And Dyslipidemias.|
|Author:||Vercesi, Anibal E|
Kowaltowski, Alicia J
Oliveira, Helena C F
Castilho, Roger F
|Abstract:||Mitochondrial Ca2+ transport is important in the maintenance of intracellular ion homeostasis, and also a key factor in the pathogenesis of many diseases. We discuss here the main aspects of mitochondrial Ca2+ transport, and how this transport is linked to changes in energy metabolism and redox state. Mitochondrial permeability transition, a consequence of excessive mitochondrial Ca2+ accumulation associated with oxidative stress is also discussed. Finally, our current understanding of the involvement of these mitochondrial processes in cardiac ischemia-reperfusion, neurodegeneration and dyslipidemias is presented.|
Reactive Oxygen Species
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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