Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196783
Type: Artigo de periódico
Title: Mitochondrial Ca2+ Transport, Permeability Transition And Oxidative Stress In Cell Death: Implications In Cardiotoxicity, Neurodegeneration And Dyslipidemias.
Author: Vercesi, Anibal E
Kowaltowski, Alicia J
Oliveira, Helena C F
Castilho, Roger F
Abstract: Mitochondrial Ca2+ transport is important in the maintenance of intracellular ion homeostasis, and also a key factor in the pathogenesis of many diseases. We discuss here the main aspects of mitochondrial Ca2+ transport, and how this transport is linked to changes in energy metabolism and redox state. Mitochondrial permeability transition, a consequence of excessive mitochondrial Ca2+ accumulation associated with oxidative stress is also discussed. Finally, our current understanding of the involvement of these mitochondrial processes in cardiac ischemia-reperfusion, neurodegeneration and dyslipidemias is presented.
Subject: Biological Transport
Calcium
Cell Death
Dyslipidemias
Heart
Humans
Mitochondria
Neurodegenerative Diseases
Oxidative Stress
Permeability
Reactive Oxygen Species
Reperfusion Injury
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/16720333
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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