Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196778
Type: Artigo de periódico
Title: Astrocyte Reactivity Influences The Number Of Presynaptic Terminals Apposed To Spinal Motoneurons After Axotomy.
Author: Emirandetti, Amanda
Graciele Zanon, Renata
Sabha, Mario
de Oliveira, Alexandre Leite Rodrigues
Abstract: Although synaptic plasticity is a widespread phenomenon, the underlying mechanisms leading to its occurrence are virtually unknown. In this sense, glial cells, especially astrocytes, may have a role in network changes of the nervous system, influencing the retraction of boutons as well as providing a proper perisynaptic environment, thereby affecting the replacement of inputs. Interestingly, the glial reaction does vary between strains of rats and mice. In this sense, we present evidence that C57BL/6J and A/J isogenic mice present different astrocyte reactivity after a peripheral lesion in vivo as well as in vitro, by analyzing primary cell cultures. Such a difference in the glial reaction has a direct influence on in vivo number of pre-synaptic terminals and on in vitro synaptogenesis.
Subject: Animals
Animals, Newborn
Astrocytes
Axotomy
Cells, Cultured
Cerebral Cortex
Cytoskeletal Proteins
Functional Laterality
Glial Fibrillary Acidic Protein
Immunohistochemistry
Indoles
Male
Mice
Mice, Inbred C57bl
Motor Neurons
Presynaptic Terminals
Spinal Cord Injuries
Statistics, Nonparametric
Synaptophysin
Rights: fechado
Identifier DOI: 10.1016/j.brainres.2006.04.021
Address: http://www.ncbi.nlm.nih.gov/pubmed/16714003
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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