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Type: Artigo de periódico
Title: Hyperbaric Oxygen Therapy Reduces The Size Of Leishmania Amazonensis-induced Soft Tissue Lesions In Mice.
Author: Arrais-Silva, Wagner Welber
Pinto, Eduardo Fonseca
Rossi-Bergmann, Bartira
Giorgio, Selma
Abstract: In this study we determined whether exposing mice to hyperbaric oxygen (HBO) would alter various disease parameters of a susceptible mouse strain infected with Leishmania amazonensis. BALB/c mice exposed to HBO (100% O2 at a pressure of 2.5 ATA, 1h before parasite inoculation and subsequently for 20 days) showed significant delay in lesion development and reduction in lesion parasite burdens compared with HBO-unexposed mice. Circulating levels of interferon gamma (IFN-gamma) and tumor necrosis factor (TNF-alpha) were significantly elevated in HBO-exposed as compared to HBO-unexposed mice. Concanavalin A-stimulated lymph nodes cultures from HBO-exposed mice released significantly more IFN-gamma and less interleukin 10 (IL-10) than cultures from HBO-unexposed mice, consistent with a skewed Th1 response. These results demonstrate, for the first time, that HBO can play a pathogen control role during leishmaniasis. Further studies are needed to elucidate whether hyperoxia alone or increased atmospheric pressure alone can exert a similar effect.
Subject: Animals
Hyperbaric Oxygenation
Lymph Nodes
Mice, Inbred Balb C
Soft Tissue Infections
Tumor Necrosis Factor-alpha
Rights: fechado
Identifier DOI: 10.1016/j.actatropica.2006.03.001
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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