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Type: Artigo de periódico
Title: Efficient Heck Arylations Of Cyclic And Acyclic Acrylate Derivatives Using Arenediazonium Tetrafluoroborates. A New Synthesis Of The Antidepressant Drug (+/-)-paroxetine.
Author: Pastre, Julio Cezar
Duarte Correia, Carlos Roque
Abstract: [reaction: see text] The Heck arylation of acyclic- and cyclic-substituted acrylates using several arenediazonium tetrafluoroborates was investigated. Arylations were carried out under aerobic, ligand-free conditions to provide the corresponding substituted acrylates in moderate to high isolated yields. Heck arylations were usually completed in less than 2 h in refluxing methanol. The aza-endocyclic acrylate derivative 11a was converted into the antidepressant drug (+/-)-paroxetine in a concise new route in good overall yield.
Subject: Antidepressive Agents
Diazonium Compounds
Molecular Structure
Citation: Organic Letters. v. 8, n. 8, p. 1657-60, 2006-Apr.
Rights: fechado
Identifier DOI: 10.1021/ol060248e
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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