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|Type:||Artigo de periódico|
|Title:||Efficient Heck Arylations Of Cyclic And Acyclic Acrylate Derivatives Using Arenediazonium Tetrafluoroborates. A New Synthesis Of The Antidepressant Drug (+/-)-paroxetine.|
|Author:||Pastre, Julio Cezar|
Duarte Correia, Carlos Roque
|Abstract:||[reaction: see text] The Heck arylation of acyclic- and cyclic-substituted acrylates using several arenediazonium tetrafluoroborates was investigated. Arylations were carried out under aerobic, ligand-free conditions to provide the corresponding substituted acrylates in moderate to high isolated yields. Heck arylations were usually completed in less than 2 h in refluxing methanol. The aza-endocyclic acrylate derivative 11a was converted into the antidepressant drug (+/-)-paroxetine in a concise new route in good overall yield.|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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