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Type: Artigo de periódico
Title: Clinicopathologic And Immunohistochemical Study Of Intraoral Mucoepidermoid Carcinoma.
Author: Lopes, Márcio Ajudarte
da Cruz Perez, Danyel Elias
de Abreu Alves, Fábio
de Almeida, Oslei Paes
Kowalski, Luiz Paulo
Abstract: The purpose of this study is to assess the clinicopathologic and immunohistochemical features of intraoral mucoepidermoid carcinomas and its relationship with the prognosis. From 1953 to 1993, 27 patients with intraoral mucoepidermoid carcinomas surgically treated were selected for this study. Clinical data were obtained from the medical records, the microscopic slides were reviewed, the tumors were graded, and immunohistochemical analysis for p53, PCNA, cerbB-2, and CEA were carried out. The tumors were more frequent in patients between 40 and 60 years of age (40.7%), without gender predilection. Hard palate was the most common site with 13 cases (48%). T2 was the more frequent stage (48%) and 2 patients (7.4%) were staged as N+. Most tumors (48%) were classified as low grade of malignancy. The expression of PCNA was associated to high-grade tumors (P = .00610) and c-erbB-2 to low grade tumors (P = .03958). No recurrence was noted in most of the cases (22 cases, 81.5%). Three cases (11.1%), however, showed local recurrence and 2 patients (7.4%) died because of the disease. The analysis of the overall survival rate showed that male patients (P = .04249), stage N (P = .05948), high grade of malignancy (P = .0009), strong expression of PCNA (P = .09128), and weak expression of c-erbB-2 (P = .03334) had the lowest survival rates. Our results showed that patients with intraoral mucoepidermoid carcinoma had a reduced survival expectation if they were of the male gender, with regional metastasis, high grade of malignancy, strong expression of PCNA and weak expression of c-erbB-2. C-4.
Subject: Adult
Antibodies, Neoplasm
Carcinoembryonic Antigen
Carcinoma, Mucoepidermoid
Disease Progression
Middle Aged
Mouth Neoplasms
Neoplasm Staging
Proliferating Cell Nuclear Antigen
Receptor, Erbb-2
Retrospective Studies
Survival Rate
Tumor Markers, Biological
Tumor Suppressor Protein P53
Citation: Otolaryngology--head And Neck Surgery : Official Journal Of American Academy Of Otolaryngology-head And Neck Surgery. v. 134, n. 4, p. 622-6, 2006-Apr.
Rights: fechado
Identifier DOI: 10.1016/j.otohns.2005.12.012
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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