Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196676
Type: Artigo de periódico
Title: Mri Volumetry Shows Increased Anterior Thalamic Volumes In Patients With Absence Seizures.
Author: Betting, Luiz Eduardo
Mory, Susana Barreto
Lopes-Cendes, Iscia
Li, Li Min
Guerreiro, Marilisa M
Guerreiro, Carlos A M
Cendes, Fernando
Abstract: The interaction between thalamus and cortex appears to be critical to the pathophysiology of idiopathic generalized epilepsies (IGEs). The objective of this study was to investigate thalamic volumes of a group of patients with IGEs using high-resolution MRI. Thalamic segmentation was performed by the same rater, who was unaware of the diagnosis. Thalamic volumes were divided into anterior half and posterior half. One hundred forty-seven patients were scanned (71 with juvenile myoclonic epilepsy, 49 with generalized tonic-clonic seizures only, and 27 with absence epilepsy). Subgroup analyses with corrections for multiple comparisons showed that, when compared with those of controls, anterior thalamic volumes were increased in patients with absence epilepsy and juvenile myoclonic epilepsy with absence seizures, but not in patients with generalized tonic-clonic seizures only and juvenile myoclonic epilepsy without absence seizures. Our results demonstrated that the anterior thalamus is structurally different in patients with IGEs and absence seizures as compared with patients with IGEs without absence seizures.
Subject: Adult
Anticonvulsants
Electroencephalography
Epilepsy, Absence
Epilepsy, Tonic-clonic
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Myoclonic Epilepsy, Juvenile
Thalamus
Rights: fechado
Identifier DOI: 10.1016/j.yebeh.2006.02.002
Address: http://www.ncbi.nlm.nih.gov/pubmed/16530016
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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