Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196652
Type: Artigo de periódico
Title: Cytotoxic Activity Of (s)-goniothalamin And Analogues Against Human Cancer Cells.
Author: Fátima, Angelo de
Kohn, Luciana K
Carvalho, João Ernesto de
Pilli, Ronaldo A
Abstract: (R)- and (S)-Goniothalamin (1) and analogues 2-9 were efficiently prepared in high overall yield and enantiomeric purity, and their cytotoxic activities were evaluated against eight human cancer cell lines. A structure-activity relationship study (SAR) allowed us to establish the relevant structural features for the cytotoxic activity of goniothalamin analogues. In addition, we have identified non-natural form of goniothalamin (S)-1 and analogue 5 as the highest and more selective cytotoxic compounds against kidney cancer cell growth (786-0) with IC50 = 4 and 5 nM, respectively, and compound 8 (IC50 = 4 nM) as the more potent against breast cancer cells with resistance phenotype for adryamycin (NCI.ADR).
Subject: Antineoplastic Agents
Breast Neoplasms
Cell Line, Tumor
Doxorubicin
Drug Resistance, Neoplasm
Female
Humans
Kidney Neoplasms
Magnetic Resonance Spectroscopy
Male
Neoplasms
Pyrones
Stereoisomerism
Structure-activity Relationship
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2005.08.036
Address: http://www.ncbi.nlm.nih.gov/pubmed/16202605
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_16202605.pdf493.08 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.