Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196638
Type: Artigo de periódico
Title: Evaluation Of Radioprotective Effect Of Vitamin E In Salivary Dysfunction In Irradiated Rats.
Author: Ramos, Flávia Maria de Moraes
Pontual, Maria Luiza Dos Anjos
de Almeida, Solange Maria
Bóscolo, Frab Norberto
Tabchoury, Cinthia Pereira Machado
Novaes, Pedro Duarte
Abstract: The aim of this study was to evaluate the radioprotective effect of vitamin E in salivary gland function, as well as analyse the total protein concentration. For this purpose 90 male rats were used and randomly divided into five experimental groups: control (I), in which animals received olive oil solution but were not irradiated; irradiated-olive oil (II), in which animals received olive oil solution and were irradiated with a single exposure dose of 15 Gy of gamma rays to the head and neck region; irradiated (III), in which animals were only irradiated with a single exposure dose of 15 Gy of gamma rays; vitamin E (IV), in which animals received alpha tocopherol acetate solution but were not irradiated; irradiated-vitamin E (V), in which animals received alpha tocopherol acetate solution before irradiation with a single exposure dose of 15 Gy gamma rays. The animals were sacrificed 4, 8 h and 30 days after the irradiation procedure. No differences were observed in salivary volumes between the groups at 4 and 8 h. At 30 days, the salivary volume in the animals pertaining to the irradiated-olive oil group was significantly reduced in relation to the control group. The only irradiated group (III) presented significantly diminished salivary volume. In the salivary composition, no significant differences were observed in the total protein content between the groups studied. It was concluded that radiation had no effect on the total protein content and that vitamin E protected the salivary function 30 days after irradiation. Thus, vitamin E can be considered as a potential radioprotective substance.
Subject: Animals
Gamma Rays
Male
Pilocarpine
Radiation Injuries
Radiation-protective Agents
Rats
Rats, Wistar
Salivary Glands
Salivary Proteins And Peptides
Salivation
Vitamin E
Rights: fechado
Identifier DOI: 10.1016/j.archoralbio.2005.06.008
Address: http://www.ncbi.nlm.nih.gov/pubmed/16087151
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_16087151.pdf131.09 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.