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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleInvestigations Of The Antioxidant Properties Of Plant Extracts Using A Dna-electrochemical Biosensor.pt_BR
dc.contributor.authorMello, Lucilene Dornellespt_BR
dc.contributor.authorHernandez, Silviapt_BR
dc.contributor.authorMarrazza, Giovannapt_BR
dc.contributor.authorMascini, Marcopt_BR
dc.contributor.authorKubota, Lauro Tatsuopt_BR
unicamp.authorLucilene Dornelles Mello, Instituto de Química, Universidade de Campinas (UNICAMP), P.O. Box 6154, 13083-970 Campinas, SP, Brazil.pt_BR
unicamp.author.externalSilvia Hernandez,pt
unicamp.author.externalGiovanna Marrazza,pt
unicamp.author.externalMarco Mascini,pt
unicamp.author.externalLauro Tatsuo Kubota,pt
dc.subjectAntioxidantspt_BR
dc.subjectBiosensing Techniquespt_BR
dc.subjectDnapt_BR
dc.subjectDna Damagept_BR
dc.subjectDrug Evaluation, Preclinicalpt_BR
dc.subjectElectrochemistrypt_BR
dc.subjectEquipment Designpt_BR
dc.subjectEquipment Failure Analysispt_BR
dc.subjectPlant Extractspt_BR
dc.description.abstractIn this work, the results of a method based on an electrochemical biosensor to detect DNA damage in vitro for the evaluation of the antioxidant properties of plant extracts are reported. The biosensor consisted of a dsDNA immobilized on a screen-printed electrode surface (SPE). DNA damage was promoted by the generation of the *OH radicals via Fenton-type reaction. The interaction of the radical species with immobilised DNA in the absence and presence of antioxidants was evaluated by means of changes in the guanine oxidation peak obtained by square wave voltammetry. The results demonstrated that the DNA-based biosensor is suitable as a rapid screening test for the evaluation of antioxidant properties of samples.en
dc.relation.ispartofBiosensors & Bioelectronicspt_BR
dc.relation.ispartofabbreviationBiosens Bioelectronpt_BR
dc.date.issued2006-Janpt_BR
dc.identifier.citationBiosensors & Bioelectronics. v. 21, n. 7, p. 1374-82, 2006-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume21pt_BR
dc.description.firstpage1374-82pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0956-5663pt_BR
dc.identifier.doi10.1016/j.bios.2005.05.012pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/16002275pt_BR
dc.date.available2015-11-27T13:05:08Z-
dc.date.accessioned2015-11-27T13:05:08Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:05:08Z (GMT). No. of bitstreams: 1 pmed_16002275.pdf: 402440 bytes, checksum: 65fda3f8bca1eec0a4974154b1c3a5c2 (MD5) Previous issue date: 2006en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196636-
dc.identifier.idPubmed16002275pt_BR
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