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Type: Artigo de periódico
Title: Investigations Of The Antioxidant Properties Of Plant Extracts Using A Dna-electrochemical Biosensor.
Author: Mello, Lucilene Dornelles
Hernandez, Silvia
Marrazza, Giovanna
Mascini, Marco
Kubota, Lauro Tatsuo
Abstract: In this work, the results of a method based on an electrochemical biosensor to detect DNA damage in vitro for the evaluation of the antioxidant properties of plant extracts are reported. The biosensor consisted of a dsDNA immobilized on a screen-printed electrode surface (SPE). DNA damage was promoted by the generation of the *OH radicals via Fenton-type reaction. The interaction of the radical species with immobilised DNA in the absence and presence of antioxidants was evaluated by means of changes in the guanine oxidation peak obtained by square wave voltammetry. The results demonstrated that the DNA-based biosensor is suitable as a rapid screening test for the evaluation of antioxidant properties of samples.
Subject: Antioxidants
Biosensing Techniques
Dna Damage
Drug Evaluation, Preclinical
Equipment Design
Equipment Failure Analysis
Plant Extracts
Citation: Biosensors & Bioelectronics. v. 21, n. 7, p. 1374-82, 2006-Jan.
Rights: fechado
Identifier DOI: 10.1016/j.bios.2005.05.012
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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