Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196631
Type: Artigo de periódico
Title: The Expression Of The Hormone Receptors In The Endometrium And Endometrial Polyps In Postmenopausal Women And Its Relationship To Body Mass Index.
Author: Belisário, Miriam Siesler Nóbrega
Vassallo, José
Andrade, Liliana A L A
Alvarenga, Marcelo
Pinto, Glauce A
Monteiro, Ilza Maria Urbano
Abstract: To evaluate and compare the relationship of body mass index (BMI) and the immunoexpression of estrogen (ER) and progesterone receptors (PR) in endometrial polyps (EP) and endometrium, in gland and stromal cells of postmenopausal women. Thirty-five postmenopausal women with benign endometrial polyps, who had not been taking medication with hormonal effects for at least 6 months, were submitted to operative hysteroscopy. The presence of ER and PR were evaluated by immunohistochemical method using a semiquantitative analysis. BMI was significantly higher among patients with lower expression of ER in the glands of endometrium (p=0.02). EP and adjacent endometrium showed significantly higher proportion of positive cells in the glands than in the stroma, for both ER (p=0.0015 and 0.0018, respectively) and PR (p=0.0176 and p<0.0001, respectively). Glands and stroma cells showed significantly higher proportion of positive cells in polyps than in the endometrium, for ER (p<0.0001 and p=0.0034, respectively). The higher proportion of positive gland cells for ER in EP as compared to endometrium supports an implication of these receptors in the pathogenesis of polyps. Association of higher BMI with lower expression of ER in endometrial glands, but not in EP, may indicate that factors influencing ER expression do not affect EP, supporting an autonomous function of polyps.
Subject: Age Factors
Aged
Aged, 80 And Over
Body Mass Index
Endometrium
Female
Humans
Immunohistochemistry
Middle Aged
Polyps
Postmenopause
Receptors, Estrogen
Receptors, Progesterone
Stromal Cells
Uterine Diseases
Rights: fechado
Identifier DOI: 10.1016/j.maturitas.2005.03.013
Address: http://www.ncbi.nlm.nih.gov/pubmed/15894442
Date Issue: 2006
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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