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Type: Artigo de periódico
Title: (r)-goniothalamin: Total Syntheses And Cytotoxic Activity Against Cancer Cell Lines.
Author: de Fátima, Angelo
Kohn, Luciana Konecny
Antônio, Márcia Aparecida
de Carvalho, João Ernesto
Pilli, Ronaldo Aloise
Abstract: The total syntheses of (R)-goniothalamin (1), a styryl lactone isolated from several Goniothalamus species, via catalytic asymmetric allylation of alpha-benzyloxyacetaldehyde (2), followed by ring-closing metathesis and Wittig olefination and via catalytic asymmetric allylation of trans-cinnamaldehyde (12), followed by ring-closing metathesis are reported. The antiproliferative activities of (R)-1 and its Z-isomer 10 as well as of the synthetic dihydropyranone intermediates 7 and 8 against eight different cancer cell lines are also described.
Subject: Annonaceae
Cell Line, Tumor
Cell Proliferation
Drug Screening Assays, Antitumor
Molecular Conformation
Citation: Bioorganic & Medicinal Chemistry. v. 13, n. 8, p. 2927-33, 2005-Apr.
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2005.02.007
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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