Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196579
Type: Artigo de periódico
Title: Antiulcerogenic Activity Of A Crude Hydroalcoholic Extract And Coumarin Isolated From Mikania Laevigata Schultz Bip.
Author: Bighetti, A E
Antônio, M A
Kohn, L K
Rehder, V L G
Foglio, M A
Possenti, A
Vilela, L
Carvalho, J E
Abstract: The leaves of Mikania (Asteraceae) species are used in folk medicine as antispasmodic, antiulcerogenic and antirheumatic agents. Phytochemical screening of the crude hydroalcoholic 70% extract (CHE) of Mikania laevigata Shultz Bip. revealed coumarins, terpenes and organic acids. Antiulcerogenic activity of CHE was evaluated, employing different experimental models in rats, to discern the pharmacological mechanism of action. Both the antisecretory and the cytoprotection hypothesis were evaluated. The crude hydroalcoholic extract (1000 mg/kg body wt., vo) decreased the ulcerative lesion index produced by indomethacin, ethanol, stress and reserpine in rats by 85%, 93%, 82% and 50%, respectively. In the pyloric ligation model, a decrease of hydrogenionic concentration (53%) was observed, suggesting that the pharmacological mechanism has a relationship to antisecretory activity. The antisecretory mechanisms of CHE and the coumarin isolated from M. laevigata were confirmed by acid hypersecretion induced by histamine, pentagastrin and bethanechol. Duodenal administration of CHE (1000 mg/kg body wt.) and coumarin (100 mg/kg body wt.) inhibited only the gastric acid secretion produced by bethanecol. These results suggest that both CHE and coumarin may influence the secretion control mediated by the parasympathetic system.
Subject: Animals
Anti-ulcer Agents
Anticoagulants
Coumarins
Disease Models, Animal
Dose-response Relationship, Drug
Duodenal Ulcer
Ethanol
Indomethacin
Male
Mikania
Phytotherapy
Plant Extracts
Plant Leaves
Rats
Rats, Wistar
Reserpine
Stress, Physiological
Rights: fechado
Identifier DOI: 10.1016/j.phymed.2003.09.006
Address: http://www.ncbi.nlm.nih.gov/pubmed/15693711
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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