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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDiagnosis Of 5alpha-reductase Type 2 Deficiency: Contribution Of Anti-müllerian Hormone Evaluation.pt_BR
dc.contributor.authorStuchi-Perez, Eliana Gpt_BR
dc.contributor.authorHackel, Christinept_BR
dc.contributor.authorOliveira, Luiz Eduardo Cpt_BR
dc.contributor.authorFerraz, Lucio F Cpt_BR
dc.contributor.authorOliveira, Laurione Cpt_BR
dc.contributor.authorNunes-Silva, Danielapt_BR
dc.contributor.authorToralles, Maria Betaniapt_BR
dc.contributor.authorSteinmetz, Leandrapt_BR
dc.contributor.authorDamiani, Durvalpt_BR
dc.contributor.authorMaciel-Guerra, Andrea Tpt_BR
dc.contributor.authorGuerra-Junior, Gilpt_BR
unicamp.authorEliana G Stuchi-Perez, Interdisciplinary Group for Study on Sex Determination and Differentiation (GIEDDS), School of Medicine, State University of Campinas (UNICAMP), Brazil.pt_BR
unicamp.author.externalChristine Hackel,pt
unicamp.author.externalLuiz Eduardo C Oliveira,pt
unicamp.author.externalLucio F C Ferraz,pt
unicamp.author.externalLaurione C Oliveira,pt
unicamp.author.externalDaniela Nunes-Silva,pt
unicamp.author.externalMaria Betania Toralles,pt
unicamp.author.externalLeandra Steinmetz,pt
unicamp.author.externalDurval Damiani,pt
unicamp.author.externalAndrea T Maciel-Guerra,pt
unicamp.author.externalGil Guerra-Junior,pt
dc.subject3-oxo-5-alpha-steroid 4-dehydrogenasept_BR
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectAnti-mullerian Hormonept_BR
dc.subjectCase-control Studiespt_BR
dc.subjectChildpt_BR
dc.subjectChild, Preschoolpt_BR
dc.subjectDihydrotestosteronept_BR
dc.subjectFemalept_BR
dc.subjectGlycoproteinspt_BR
dc.subjectHumanspt_BR
dc.subjectInfantpt_BR
dc.subjectInfant, Newbornpt_BR
dc.subjectMalept_BR
dc.subjectOrchiectomypt_BR
dc.subjectTesticular Hormonespt_BR
dc.subjectTestosteronept_BR
dc.description.abstractTo evaluate anti-Müllerian hormone (AMH) levels in patients with clinical and molecular diagnosis of 5alpha-reductase 2 deficiency. Data from 14 patients whose age ranged from 21 days to 29 years were analyzed according to age and pubertal stage. Sexual ambiguity was rated as Prader III in 11 patients. LH, FSH, testosterone (T), dihydrotestosterone (DHT) and AMH serum levels were measured in all but two patients, who had been previously submitted to gonadectomy; T and DHT were also measured in 20 age-matched controls. Gonadotropin levels were normal in all but one patient who retained gonads (six of whom had reached puberty) and T/DHT ratio was elevated in all patients when compared to controls. All prepubertal patients had AMH levels < -1 SD for age, while most pubertal patients had AMH levels compatible with pubertal stage. Prepubertal patients with 5alpha-reductase 2 deficiency have AMH values in the lower part of the normal range. These data indicate that T does not need to be converted to DHT to inhibit AMH secretion by Sertoli cells.en
dc.relation.ispartofJournal Of Pediatric Endocrinology & Metabolism : Jpempt_BR
dc.relation.ispartofabbreviationJ. Pediatr. Endocrinol. Metab.pt_BR
dc.date.issued2005-Decpt_BR
dc.identifier.citationJournal Of Pediatric Endocrinology & Metabolism : Jpem. v. 18, n. 12, p. 1383-9, 2005-Dec.pt_BR
dc.language.isoengpt_BR
dc.description.volume18pt_BR
dc.description.firstpage1383-9pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0334-018Xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/16459464pt_BR
dc.date.available2015-11-27T13:02:42Z-
dc.date.accessioned2015-11-27T13:02:42Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:02:42Z (GMT). No. of bitstreams: 1 pmed_16459464.pdf: 1424063 bytes, checksum: 607a6b827c9980714ddbfa617fbdb17a (MD5) Previous issue date: 2005en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196545-
dc.identifier.idPubmed16459464pt_BR
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