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Type: Artigo de periódico
Title: Aided Visual Inspection With Acetic Acid (via) And Hpv Detection As Optional Screening Tools For Cervical Cancer And Its Precursor Lesions.
Author: Bragança, J F
Derchain, S F
Sarian, L O
Messias da Silva, S M
Labatte, S
Zeferino, L C
Abstract: To assess the contribution of visual inspection with acetic acid (VIA) and Hybrid Capture II (HCII) as adjunct methods to the Pap test in detecting cervical neoplasia. This was a cross-sectional study with 809 women who consecutively attended gynecological consultations at Campinas University, Brazil, from January 2002 to July 2003. Pap test, HCII, VIA, and colposcopy were offered to all patients. Performance of tests (alone or in combination) in detecting histologically confirmed lesions was evaluated. Of the 40 patients with CIN, 69% had CIN1, 26% CIN2 or CIN3 and one patient had invasive carcinoma. VIA had the best performance in detecting CIN, yielding 72% sensitivity and 91% specificity. Considering only CIN2 or worse as significant lesions, HCII had the best sensitivity (73%), while the Pap test was the most specific (93%). Combining the three exams, 92% of the CIN1 or worse were detected. When CIN1 was excluded from the analysis, Pap smear plus HCII delivered 82% sensitivity and 79% specificity. However, this combination yielded a very low (5%) PPV. VIA and HCII contributed to the screening of cervical neoplasia in a group of Brazilian women, but the cost-effectiveness of conjoint screening modalities is still debatable.
Subject: Acetic Acid
Cervical Intraepithelial Neoplasia
Cervix Uteri
Cross-sectional Studies
Dna Probes, Hpv
Middle Aged
Neoplasm Staging
Papanicolaou Test
Papillomavirus Infections
Physical Examination
Prospective Studies
Sensitivity And Specificity
Uterine Cervical Neoplasms
Vaginal Smears
Rights: fechado
Identifier DOI: 
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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