Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196535
Type: Artigo de periódico
Title: Acute Myocardial Infarction In Sickle Cell Disease: A Possible Complication Of Hydroxyurea Treatment.
Author: Fattori, André
de Souza, Robenílson Almeida
Saad, Sara Terezinha Olalla
Costa, Fernando Ferreira
Abstract: We describe a 28-year-old man treated with hydroxyurea for sickle cell anemia, who was admitted to the University Hospital with an acute myocardial infarction. The patient had evolved high hematocrit values during his long-term hydroxyurea treatment, suggesting a correlation between a possible increment in blood viscosity and the coronary occlusion without previous lesions. Indeed, several studies associate vasocclusive episodes and severe clinical course with high viscosity. Although hydroxyurea is considered an effective therapeutic option for these patients, care should be taken to monitor hematocrit levels and possible complications. Hematocrit and hemoglobin values of above 30% and 10.5 g/dl in SS patients on hydroxyurea therapy should be avoided or closely monitored.
Subject: Adult
Anemia, Sickle Cell
Antisickling Agents
Blood Viscosity
Hematocrit
Hemoglobins
Humans
Hydroxyurea
Male
Myocardial Infarction
Rights: fechado
Identifier DOI: 10.1038/sj.thj.6200572
Address: http://www.ncbi.nlm.nih.gov/pubmed/15692605
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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