Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196534
Type: Artigo de periódico
Title: Statistical Voxel-wise Analysis Of Ictal Spect Reveals Pattern Of Abnormal Perfusion In Patients With Temporal Lobe Epilepsy.
Author: Amorim, Bárbara Juarez
Etchebehere, Elba Cristina Sá de Camargo
Camargo, Edwaldo Eduardo
Rio, Pablo Augusto
Bonilha, Leonardo
Rorden, Chris
Li, Li Min
Cendes, Fernando
Abstract: To investigate the pattern of perfusion abnormalities in ictal and interictal brain perfusion SPECT images (BSI) from patients with temporal lobe epilepsy (TLE). It was acquired interictal and ictal BSI from 24 patients with refractory TLE. BSIs were analyzed by visual inspection and statistical parametric mapping (SPM2). Statistical analysis compared the patients group to a control group of 50 volunteers. The images from patients with left-TLE were left-right flipped. It was not observed significant perfusional differences in interictal scans with SPM. Ictal BSI in SPM analysis revealed hyperperfusion within ipsilateral temporal lobe (epileptogenic focus) and also contralateral parieto-occipital region, ipsilateral posterior cingulate gyrus, occipital lobes and ipsilateral basal ganglia. Ictal BSI also showed areas of hypoperfusion. In a group analysis of ictal BSI of patients with TLE, voxel-wise analysis detects a network of distant regions of perfusional alteration which may play active role in seizure genesis and propagation.
Subject: Adolescent
Adult
Brain
Case-control Studies
Cerebrovascular Circulation
Child
Child, Preschool
Chronic Disease
Data Interpretation, Statistical
Epilepsy, Temporal Lobe
Female
Humans
Male
Middle Aged
Tomography, Emission-computed, Single-photon
Rights: aberto
Identifier DOI: /S0004-282X2005000600014
Address: http://www.ncbi.nlm.nih.gov/pubmed/16400416
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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