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Type: Artigo de periódico
Title: Low-fluoride Dentifrice And Gastrointestinal Fluoride Absorption After Meals.
Author: Cury, J A
Del Fiol, F S
Tenuta, L M A
Rosalen, P L
Abstract: A low-fluoride (F) dentifrice has been recommended to reduce the risk of dental fluorosis, but its anti-caries efficacy is questionable compared with that of conventional dentrifices (1000-1100 microg F/g). The tested hypothesis was that conventional dentifrices might be safe if used soon after meals, since food interferes with F absorption. In a crossover, double-blind study, 11 volunteers ingested a dentifrice slurry containing 0 (placebo), 550 (low F), or 1100 microg F/g in 3 gastric content situations: on fasting, or 15 min after breakfast or lunch. F was analyzed in saliva and 24-hour urine samples. The conventional dentifrice ingested after lunch resulted in only 10% higher F absorption than the low-F ingested on fasting. Analysis of the data suggests that the risk of fluorosis could be reduced by the use of either a low-F dentifrice or a conventional dentifrice, if toothbrushing occurred soon after meals.
Subject: Absorption
Area Under Curve
Biological Availability
Cariostatic Agents
Cross-over Studies
Double-blind Method
Gastrointestinal Contents
Gastrointestinal Tract
Rights: fechado
Identifier DOI: 
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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